Medchemexpress LLC GCN2-IN-6 | 2183470-09-7 | >98.89% | 100 MG

Supplier:  Medchemexpress LLC HY130240100MG

GCN2-IN-6 (Compound 6d) is a potent and orally available GCN2 inhibitor. It demonstrates high efficacy with an in-house enzymatic IC50 of 1.8 nM and a cellular IC50 of 9.3 nM. This compound also functions as an eIF2α kinase PERK inhibitor, exhibiting an IC50 of 0.26 nM in enzymatic assays and 230 nM in cells. Additionally, GCN2-IN-6 is designed as a click chemistry reagent, containing an Alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.

• Potent GCN2 inhibitor with high enzymatic and cellular efficacy
• Orally available for ease of administration
• Acts as an eIF2α kinase PERK inhibitor
• Features an Alkyne group for click chemistry applications
• Enables copper-catalyzed azide-alkyne cycloaddition reactions

Catalog No. 50-003-38853