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Medchemexpress LLC GCN2-IN-6 | 2183470-09-7 | 98.89% | 50 MG
Supplier: Medchemexpress LLC HY13024050MG
GCN2-IN-6 (Compound 6d) is a potent, orally available GCN2 inhibitor with an IC50 of 1.8 nM in enzymatic assays and 9.3 nM in cellular assays. It also acts as an eIF2α kinase PERK inhibitor, showing an IC50 of 0.26 nM (enzymatic) and 230 nM (cellular). This compound is a click chemistry reagent, featuring an Alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with Azide-containing molecules.
- Potent and orally available GCN2 inhibitor.
- Acts as an eIF2α kinase PERK inhibitor.
- Functions as a click chemistry reagent.
- Sensitizes acute lymphoblastic leukemia cells to asparaginase.
- Suppresses p-GCN2, p-eIF2α, and ATF4 activation.
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