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Apexbio Technology LLC GDC-0032 1282512-48-4 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B10475.1
GDC-0032 (CAS 1282512-48-4) is a benzofused small-molecule inhibitor targeting PI3K with high potency and selectivity It demonstrates strong inhibitory activity against PI3K PI3K and PI3K with IC50 values of 0 29 nM 0 91 nM and 0 97 nM respectively and notably exhibits greater selectivity towards PI3K In vitro GDC-0032 effectively inhibits cell proliferation and cellular function showing EC50 values of 25 nM (MCF7 cells) and 571 nM (PC3 cells) with corresponding IC50 values of 4 nM and 31 nM In vivo experiments indicate antitumor activity in MCF7-neo/Her2 xenograft models GDC-0032 serves as a valuable tool compound for PI3K-related oncology research
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