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Apexbio Technology LLC GDC-0068 (RG7440) 1001264-89-6 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A30065.1
GDC-0068 (RG7440 CAS number 1001264-89-6) is a selective small-molecule inhibitor targeting Akt isoforms Akt1 Akt2 and Akt3 It inhibits Akt activity with IC50 values of 5 nM 18 nM and 8 nM for Akt1 Akt2 and Akt3 respectively Akt signaling within the PI3K-Akt pathway regulates cellular proliferation survival and tumorigenesis and is frequently dysregulated in cancers harboring mutations in PTEN or PI3K GDC-0068 binds to and inhibits Akt activation resulting in reduced tumor cell proliferation cell-cycle arrest and induction of apoptosis supporting its utility in oncology research
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