Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 5000063022

Apexbio Technology LLC GDC-0449 (Vismodegib) 879085-55-9 10mM (in 1mL DMSO)
SDP

Supplier:  Apexbio Technology LLC A30215.1

Encompass_Preferred

GDC-0449 (Vismodegib CAS 879085-55-9) is a small molecule that selectively inhibits the Hedgehog (Hh) signaling pathway by binding to the Smoothened (SMO) receptor thus preventing downstream activation of Hh target genes implicated in cellular proliferation and differentiation This compound emerged from screening small-molecule libraries followed by medicinal chemistry optimization Preclinical evaluation demonstrated antitumor activity in murine models of medulloblastoma and xenograft models derived from human colon and pancreatic cancers Currently GDC-0449 is under investigation for locally advanced and metastatic solid tumors

Catalog No. 50-000-63022


May include imposed supplier surcharges.
Only null left
Add to Cart

Product Content Correction

The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.