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Apexbio Technology LLC GDC-0941 dimethanesulfonate 957054-33-0 200mg
SDP

Catalog No. 5000096855
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GDC-0941 dimethanesulfonate (CAS 957054-33-0) is a thieno[3 2-d]pyrimidine-based small molecule inhibitor targeting class I phosphoinositide 3-kinases (PI3K) It competitively binds the ATP-binding site of PI3K thereby suppressing synthesis of phosphatidylinositol-3 4 5-trisphosphate (PIP3) and downstream Akt signaling a pathway frequently dysregulated in cancer GDC-0941 exhibits high selectivity for PI3K and PI3K isoforms (IC50 3 nM) with moderate selectivity toward PI3K and PI3K In vitro and in vivo studies show inhibition of proliferation in various cancer cell lines including HER2-amplified and drug-resistant models and reduction of tumor volume in xenograft models GDC-0941 is orally bioavailable and serves as a valuable tool for exploring PI3K pathway function in oncology research

Catalog No. 50-000-96855 Supplier Apexbio Technology LLC Supplier No. A3432200
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GDC-0941 dimethanesulfonate (CAS 957054-33-0) is a thieno[3 2-d]pyrimidine-based small molecule inhibitor targeting class I phosphoinositide 3-kinases (PI3K) It competitively binds the ATP-binding site of PI3K thereby suppressing synthesis of phosphatidylinositol-3 4 5-trisphosphate (PIP3) and downstream Akt signaling a pathway frequently dysregulated in cancer GDC-0941 exhibits high selectivity for PI3K and PI3K isoforms (IC50 3 nM) with moderate selectivity toward PI3K and PI3K In vitro and in vivo studies show inhibition of proliferation in various cancer cell lines including HER2-amplified and drug-resistant models and reduction of tumor volume in xenograft models GDC-0941 is orally bioavailable and serves as a valuable tool for exploring PI3K pathway function in oncology research

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