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Medchemexpress LLC GDP366 | 501698-03-9 | 375.45 | 25 MG
Supplier: Medchemexpress LLC 25MGHYU00177
GDP366 is a dual inhibitor of survivin and Op18, inducing cell growth inhibition, cellular senescence, and mitotic catastrophe in human cancer cells. It significantly inhibits tumor cell growth in vitro and in vivo (nude mouse model) without rapid induction of apoptosis.
- Potently and selectively inhibits the expression of both survivin and Op18
- Decreases both mRNA and protein levels of survivin and Op18
- Inhibitory effect is independent of p53 and p21 status
- Induces polyploidy in multiple types of cancer cell lines
- Increases chromosomal instability and induces cellular senescence by inhibiting telomerase activity
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