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AdipoGen GE81112 A B
SDP

Supplier:  AdipoGen AGCN20306M025

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Chemical. CAS 883726-13-4 GE81112A, 883726-14-5 GE81112B. Formula C24H34ClN9O10 A, C24H35ClN10O10 B. MW 644.0 A659.1 B. Isolated from Strepomyces sp. Tetrapeptide antibiotic. Potent and selective inhibitor of bacterial protein synthesis. Translational inhibitor specific for the initiation phase. Binds to the 30S ribosomal subunit and specifically inhibits P-site decoding of the mRNA initiation codon by the fMet-tRNA anticodon. Inhibits in vivo protein synthesis but not other cell functions such as DNA duplication, transcription and cell wall synthesis. Antibacterial activity against some Gram-positive and Gram-negative bacteria. Unique scaffold for designing new drugs.

Catalog No. 50-256-2622


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