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Medchemexpress LLC Gefitinib-d6 | 1228664-49-0 | 98.0% | C22H18D6ClFN4O3 | 1 MG
Supplier: Medchemexpress LLC HY50895S11MG
Gefitinib-d6 is the deuterium labeled Gefitinib. Gefitinib (ZD1839) is a potent, selective, and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. It selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy and has antitumour activity. Deuterium substitution has the potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
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