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Apexbio Technology LLC Gefitinib (ZD1839) 184475-35-2 10mM (in 1mL DMSO)
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Supplier:  Apexbio Technology LLC A82195.1

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Gefitinib (ZD1839 CAS 184475-35-2) is an orally bioavailable small-molecule inhibitor that specifically targets epidermal growth factor receptor (EGFR) tyrosine kinase Acting competitively by occupying the ATP-binding domain of EGFR gefitinib blocks ATP interaction and thereby inhibits EGFR autophosphorylation and downstream signaling In biochemical assays gefitinib demonstrates IC50 values of 0 033 M and 0 027 M against EGFR tyrosine kinase activity in A431 membrane preparations and baculovirus lysates respectively Consequently gefitinib suppresses tumor proliferation induces apoptosis and exhibits activity in models of various solid tumors including lung colorectal breast head and neck prostate and ovarian cancers

Catalog No. 50-000-62104


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