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AdipoGen Geldanamycin

Supplier: AdipoGen BVT0196C500

Chemical. CAS 30562-34-6. Formula C29H40N2O9. MW 560.6. Isolated from Streptomyces hygroscopicus. Antibiotic. Potent antitumor compound. pp60src tyrosine kinase inhibitor. Inhibits c-mycgene expression in murine lymphoblastoma cells. Inhibits the transforming activity of abl, erbB, fps, src and yes. Binds specifically to heat shock protein 90 HSP90 and to its endoplasmic reticulum homolog GP96 GRP94. Destabilizes several oncogene and proto-oncogene products. Potent nuclear hormone receptor family inhibitor.
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