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  6. Geldanamycin, 98+%

Geldanamycin, 98+%

Catalog No. AAJ63397MB
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Catalog No. AAJ63397MB Supplier Thermo Scientific Chemicals Supplier No. J63397MB
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Description

Benzoquinoid antibiotic that inhibits pp60src tyrosine kinase | CAS: 30562-34-6 | C29H40N2O9 | 560.644 g/mol

Geldanamycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins. It interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Geldanamycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins. It interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.

Solubility
Soluble in dimethyl sulfoxide at 100 mg/mL.

Notes
Store in a cool dry place. Keep away from oxidizing agents. Protect from heat.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 30562-34-6
Molecular Formula C29H40N2O9
Molecular Weight (g/mol) 560.644
MDL Number MFCD00274570
InChI Key QTQAWLPCGQOSGP-KDFVLELPSA-N
Synonym NSC 122750; U-29135
PubChem CID 133688416
IUPAC Name [(3S,5R,6S,7R,8Z,11R,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
SMILES CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)C)OC)OC(=O)N)C)C)O)OC

Specifications

Type Geldanamycin
Physical Form Powder
Color Orange to Yellow
Quantity 25 mg
Solubility Information Soluble in dimethyl sulfoxide at 100mg/mL.
Formula Weight 560.64
Percent Purity ≥99%
Chemical Name or Material Geldanamycin

Safety and Handling

RTECSNumber LX8920000
TSCA No
Recommended Storage Store at -20°C
SDS

RUO – Research Use Only

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