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Medchemexpress LLC Gemcitabine Hydrochloride | 122111-03-9 | 99.9% | C9H11F2N3O4 · HCl | 5 G
Supplier: Medchemexpress LLC HYB00035G
Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. It works by inhibiting DNA synthesis and repair, ultimately leading to autophagy and apoptosis.
- Targets DNA synthesis.
- Inhibits the growth of various cancer cell lines, including BxPC-3, Mia Paca-2, PANC-1, PL-45, and AsPC-1.
- Effectively kills both mouse and human senescent cells in vitro.
- Demonstrates increased survival time in mouse models when combined with DMAPT.
- Can be administered via endotracheal spray in rats with lower toxicity compared to oral administration at certain dosages.
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