AdipoGen Gemcitabine hydrochloride

Supplier:  AdipoGen CDXG0063M050

Chemical. CAS 122111-03-9. Formula C9H11F2N3O4 . HCl. MW 263.20 . 36.46. Synthetic. Widely used antitumor agent in vitro and in vivo. Deoxycytidine analog with cytotoxic effects. Inhibits DNA synthesis and induces apoptosis through inhibition of ribonucleotide reductase R1 and R2. Following the uptake of this prodrug into cells by nucleoside transporters it is phosphorylated to its monodFdCMP, didFdCDP, and triphosphorylateddFdCTP forms by deoxycytidine kinase. dFdCDP and dFdCTP are reported to inhibit the activity of ribonucleotide reductase and impede DNA synthesis and repair mechanisms and induce cell death. The triphosphate form is incorporated into DNA which induces masked chain termination and cell death. By specifically inhibiting growth arrest and DNA damage inducible protein 45 a Gadd45a, a key mediator of active DNA demethylation, inhibits repair-mediated DNA demethylation in a methylation-sensitive reporter assay at concentrations ranging from 34-134nM.

Catalog No. 50-256-0818