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AdipoGen Genistein
Supplier: AdipoGen CDXG0210M025
Chemical. CAS 446-72-0. Formula C15H10O5. MW 270.24. Genistein is an isoflavonoid phytoestrogen that has been found in soybeans and has kinase inhibitory, anticancer, pro-cancer and hepatoprotective properties. It is a cell-permeable, reversible, substrate competitive tyrosine kinase inhibitor including EGFR phosphorylation, implicated in almost all cell growth and proliferation signal cascades. Genistein inhibits proliferation and induces cell cycle arrest and apoptosis in a variety of cancer cells. It is antiangiogenic agent, down-regulates the transcription of genes involved in controlling angiogenesis. On a molecular level it also inhibits mammalian DNA topoisomerase II and DNA methyltransferase, and binds to estrogen receptor beta. Genistein has also antidiabetic, anti-inflammatory, antimicrobial and antioxidant properties.
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