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Medchemexpress LLC Genz-123346 free base | 491833-30-8 | 99.6% | 1 ML
SDP

Catalog No. 5000338459
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This compound is an orally available inhibitor of glucosylceramide synthase. It functions by blocking the conversion of ceramide to glucosylceramide (GL1) and demonstrates inhibition of GM1 with an IC50 of 14 nM.

  • Orally available inhibitor of glucosylceramide synthase.
  • Blocks ceramide conversion to glucosylceramide.
  • Inhibits GM1 with high potency.
  • Enhances anti-cancer agent efficacy against tumor cells.
  • Modulates drug resistance efflux pump function.
  • Enhances autophagy flux in neurons.
  • Lowers glucose and A1C levels, improving glucose tolerance.
  • Preserves pancreatic beta-cell function and insulin secretion.
  • Reduces renal glycosphingolipid levels, preventing cystic disease.
  • Impacts the Akt-mTOR signaling pathway.

Catalog No. 50-003-38459 Supplier Medchemexpress LLC Supplier No. HY1274410MM/1ML
May include imposed supplier surcharges.
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This compound is an orally available inhibitor of glucosylceramide synthase. It functions by blocking the conversion of ceramide to glucosylceramide (GL1) and demonstrates inhibition of GM1 with an IC50 of 14 nM.

  • Orally available inhibitor of glucosylceramide synthase.
  • Blocks ceramide conversion to glucosylceramide.
  • Inhibits GM1 with high potency.
  • Enhances anti-cancer agent efficacy against tumor cells.
  • Modulates drug resistance efflux pump function.
  • Enhances autophagy flux in neurons.
  • Lowers glucose and A1C levels, improving glucose tolerance.
  • Preserves pancreatic beta-cell function and insulin secretion.
  • Reduces renal glycosphingolipid levels, preventing cystic disease.
  • Impacts the Akt-mTOR signaling pathway.

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