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Medchemexpress LLC Genz-123346 free base | 491833-30-8 | 99.6% | 10 MG
SDP

Catalog No. 5000342644
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Genz-123346 free base is an orally available inhibitor of glucosylceramide synthase. It blocks the conversion of ceramide to glucosylceramide (GL1) and inhibits GM1 with an IC50 of 14 nM. This product is for research use only.

  • Potent inhibitor of glucosylceramide synthase and GM1.
  • Enhances tumor cell killing by cytotoxic anti-cancer agents through P-gp function modulation.
  • Enhancer of autophagy flux.
  • In vivo, improves glycemic control, insulin sensitivity, and preserves beta-cell function.
  • Normalizes A1C levels and improves glucose tolerance in diet-induced obese mice.
  • Blocks polycystic kidney disease by reducing renal GlcCer and GM3 levels.
  • Affects Akt-mTOR signaling pathway, reducing Akt and ribosomal protein S6 phosphorylation.

Catalog No. 50-003-42644 Supplier Medchemexpress LLC Supplier No. HY1274410MG
May include imposed supplier surcharges.
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Genz-123346 free base is an orally available inhibitor of glucosylceramide synthase. It blocks the conversion of ceramide to glucosylceramide (GL1) and inhibits GM1 with an IC50 of 14 nM. This product is for research use only.

  • Potent inhibitor of glucosylceramide synthase and GM1.
  • Enhances tumor cell killing by cytotoxic anti-cancer agents through P-gp function modulation.
  • Enhancer of autophagy flux.
  • In vivo, improves glycemic control, insulin sensitivity, and preserves beta-cell function.
  • Normalizes A1C levels and improves glucose tolerance in diet-induced obese mice.
  • Blocks polycystic kidney disease by reducing renal GlcCer and GM3 levels.
  • Affects Akt-mTOR signaling pathway, reducing Akt and ribosomal protein S6 phosphorylation.

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