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Medchemexpress LLC GGTI-2154 (hydrochloride) | 478908-50-8 | 98.1% | 456.97 | 25 MG
Supplier: Medchemexpress LLC 25MGHY16229A
GGTI-2154 hydrochloride is a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I), with an IC50 of 21 nM. It demonstrates over 200-fold selectivity for GGTase I compared to FTase (IC50=5600 nM). This product is suitable for cancer research. It is for research use only and not sold to patients.
- Potent and selective inhibitor of geranylgeranyltransferase I (GGTase I) with an IC50 of 21 nM.
- Shows more than 200-fold selectivity for GGTase I over FTase (IC50=5600 nM).
- Can be used for cancer research.
- Induces breast tumor regression in MMTV-ν-Ha-Ras transgenic mice (100 mg/kg/day; s.c. for 14 days).
- Inhibits A-549 tumor growth in nude mice by 60% (50 mg/kg/day; i.p. for 50 days).
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