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Gibco™ Mouse IFN-gamma Recombinant Protein

Catalog No. PMC4034
Encompass_Preferred
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Quantity:
1 mg
100 μg
15 μg

Recombinant Protein

Purity: >95% by SDS-PAGE, Endotoxin Concentration: <0.1 ng/mL, Biological Activity: ED50 <0.600 ng/mL, Molecular Weight: 15 kDa

IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor, and immune interferon that is produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemaglutanin and other cytokines. IFN gamma is a dimeric protein consisting of two 146 amino acid subunits. IFN gamma is a glycoprotein that exists, functionally, as a homodimer of approximately 45 kDa. On SDS-PAGE, IFN gamma appears as a combination of 25, 20 and minor 15.5 kDa bands as a result of differential glycosylation. The biological activity of the IFN gamma homodimer is highly species specific. Human IFN gamma does not show cross-reactivity with mouse. IFN gamma function includes the following: antiviral activity, tumor antiproliferative activity, induction of class I and II MHC, macrophage activation, and enhanced immunoglobulin secretion by B lymphocytes. IFN gamma is involved in cytokine regulation and also acts synergistically with other cytokines. Activation of IFN gamma takes place through binding of IFN gamma receptor I and II, and activating the JAK-STAT pathway. IFN gamma does not show any homology with IFN alpha or IFN beta but human IFN gamma shows about 40% sequence homology with mouse IFN gamma. IFN gamma is upregulated by IL2, FGF basic, EGF and downregulated by vitamin D3 or DMN. IFN gamma gene mutations are associated with aplastic anemia.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P01580
For Use With (Application) Control, ELISA, Functional Assay, Immunohistochemistry, Western Blot
Formulation tris with no preservative; pH 7.4
Gene ID (Entrez) 15978
Molecular Weight (g/mol) 15 kDa
Name Mouse IFN-gamma
Purification Method Sequential Chromatography
Quantity 15 μg
Endotoxin Concentration <0.1 ng/mL
Gene Alias BoIFNG; cytokine; EGK_03901; gamma interferon; gamma interferon precursor; gamma-interferon; gamma-interferon precursor (AA -23 to 143); H-IFN-g; IFG; IFI; IFN gamma; IFN ?; Ifng; IFN-g; IFNG2; IFN-gamma; IFN-gamma precursor; IFN-y; IFN?; Immune interferon; Interferon; interferon gamma; interferon gamma precursor; interferon gamma type 2; Interferon y; Interferon ?; interferon, gamma; interferon-gama; interferon-gamma; Interferon-gamma level; interferon-gamma precursor; Interferon?; M-IFN-g; R-IFN-g
Common Name IFN gamma
Biological Activity ED50 < 0.6 ng/mL; determined by a dose-dependent cytostasis assay of mouse WeHi279 cells.
Conjugate Unconjugated
Species Mouse
Recombinant Recombinant
Sequence CYCHGTVIES LESLNNYFNS SGIDVEEKSL FLDIWRNWQK DGDMKILQSQ IISFYLRLFE VLKDNQAISN NISVIESHLI TTFFSNSKAK KDAFMSIAKF EVNNPQVQRQ AFNELIRVVH QLLPESSLRK RKRSR
Content And Storage -80°C
Endotoxin Level <0.1 ng/ml
Shipping Condition Dry Ice
Expression System E. coli
Protein Family Cytokines & Receptors
Protein Form Recombinant, Ligand, Mutant
Form Liquid
Protein Subtype Interferons
Research Category Immunology, Virology, Oncology, Signal Transduction
Product Line Gibco™
Purity or Quality Grade >95% by SDS-PAGE
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WARNING: Cancer - www.P65Warnings.ca.gov
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