Gibco™ Human TGF-beta 3 Recombinant Protein

Catalog No.	Quantity
PHG9305	5 μg

Catalog No. PHG9305 Supplier Gibco™ Supplier No. PHG9305

Description

Recombinant Protein

Purity: >98% by SDS-PAGE and HPLC, Endotoxin Concentration: <0.1 ng/μg, Protein Length: 112 aa (2 identical subunits), Biological Activity: ED50 ≤0.05 ng/mL, Molecular Weight: 17.5 kDa

Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.

Specifications

• Accession Number: P10600
• For Use With (Application): Control, ELISA, Functional Assay, Immunohistochemistry, Western Blot
• Formulation: 0.12% acetic acid with 20% ethanol and no preservative
• Gene ID (Entrez): 7043
• Molecular Weight (g/mol): 25.4 kDa
• Name: Human TGF-beta 3
• Purification Method: Sequential Chromatography
• Quantity: 5 μg
• Source: Human
• Endotoxin Concentration: <0.1 ng/ μg
• Gene Alias: ARVD; ARVD1; FLJ16571; H-TGF-b-3; LAP; Latency-associated peptide; LDS5; prepro-transforming growth factor beta-3; RNHF; TGF beta 3; Tgfb3; TGF-B3; Tgfb-3; TGF-beta3; TGF-beta-3; Transforming growth factor; transforming growth factor beta 3; transforming growth factor beta precursor; transforming growth factor beta-3; Transforming growth factor beta-3 proprotein; transforming growth factor, beta 3; transforming growth factor-beta3
• Common Name: TGF beta-3
• Biological Activity: ED50 ≤ 0.05 ng/mL (≥ 12.5 x 10e6 IU/mg); determined by a toxicity assay using the WHO Standard 98/608 for direct comparison.
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: Human TGF-beta 3 recombinant protein is a homodimer containing two 112 amino acid subunits
• Content And Storage: 4°C
• Expression System: E. coli
• Protein Family: Growth Factors & Receptors
• Form: Liquid
• Protein Subtype: TGFs (Transforming Growth Factors)
• Purity or Quality Grade: >98% by SDS-PAGE and HPLC