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Medchemexpress LLC Givinostat (hydrochloride) | 199657-29-9 | 98.1% | 457.95 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY14842A10MM/1ML

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Givinostat (ITF-2357) hydrochloride is an HDAC inhibitor that can penetrate the blood-brain barrier (BBB). It demonstrates inhibitory activity against various HDACs, including HDAC1 (IC50: 198 nM) and HDAC3 (IC50: 157 nM).

  • Targets multiple HDACs, including hHDAC1, hHDAC3, hHDAC11, hHDAC6, hHDAC2, hHDAC10, hHDAC7, hHDAC5, hHDAC9, hHDAC8, and hHDAC4.
  • Suppresses LPS-induced IL-1β production by over 70%.
  • Reduces IL-6 production in PBMCs stimulated with TLR agonists.
  • Inhibits JS-1 cell proliferation.
  • Reduces serum TNFα in vivo.

Catalog No. 50-003-62076


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