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Medchemexpress LLC Givinostat hydrochloride | 199657-29-9 | MFCD28502062 | 98.1% | 457.95 | 100 MG
Supplier: Medchemexpress LLC HY14842A100MG
Givinostat hydrochloride is a Histone Deacetylase (HDAC) inhibitor that can penetrate the blood-brain barrier (BBB). It is known to inhibit HDAC1 and HDAC3, and has shown efficacy in suppressing inflammatory responses and inhibiting cell proliferation in various studies.
- Inhibits HDAC1 (IC50: 198 nM) and HDAC3 (IC50: 157 nM)
- Penetrates the blood-brain barrier (BBB)
- Suppresses LPS-induced IL-1β production
- Decreases IL-6 secretion in PBMCs
- Inhibits JS-1 cell proliferation
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