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Cayman Chemical GlecaprevIr 10mg
SDP

Catalog No. 502940283
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An HCV NS3/4A protease inhibitor; inhibits NS3/4A from HCV genotypes 1a, 1b, 2a, 2b, 3a, 4a, 5a, and 6a (IC50s = 4.6, 8.9, 3.5, 3.8, 7.9, 6.1, 8.1, and 11.3 nM) in cell-free assays but does not inhibit human chymase, chymotrypsin type II, chymotrypsin type VII, elastase, kallikrein, urokinase, or cathepsin B proteases (IC50s = >200,000 nM); inhibits HCV replication in stable Huh7-derived replicon cell lines infected with subgenomic genotypes 1a, 1b, 2a, 2b, 3a, 4a, 5a, and 6a (EC50s = 0.85, 0.94, 2.2, 4.6, 1.9, 2.8, 1.4, and 0.86 nM, respectively); inhibits replication of clinical isolates of genotypes 1a (EC50s = 0.05-0.12 nM), 1b (EC50s = 0.20- 0.68 nM), 2a (EC50s = 0.66- 1.9 nM), 2b (EC50s = 1.4- 3.2 nM), 3a (EC50s = 0.71- 3.8 nM), and 4a (EC50s = 0.31- 0.55 nM)

Catalog No. 50-294-0283 Supplier Cayman Chemical Supplier No. 2793410 MG
May include imposed supplier surcharges.
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An HCV NS3/4A protease inhibitor; inhibits NS3/4A from HCV genotypes 1a, 1b, 2a, 2b, 3a, 4a, 5a, and 6a (IC50s = 4.6, 8.9, 3.5, 3.8, 7.9, 6.1, 8.1, and 11.3 nM) in cell-free assays but does not inhibit human chymase, chymotrypsin type II, chymotrypsin type VII, elastase, kallikrein, urokinase, or cathepsin B proteases (IC50s = >200,000 nM); inhibits HCV replication in stable Huh7-derived replicon cell lines infected with subgenomic genotypes 1a, 1b, 2a, 2b, 3a, 4a, 5a, and 6a (EC50s = 0.85, 0.94, 2.2, 4.6, 1.9, 2.8, 1.4, and 0.86 nM, respectively); inhibits replication of clinical isolates of genotypes 1a (EC50s = 0.05-0.12 nM), 1b (EC50s = 0.20- 0.68 nM), 2a (EC50s = 0.66- 1.9 nM), 2b (EC50s = 1.4- 3.2 nM), 3a (EC50s = 0.71- 3.8 nM), and 4a (EC50s = 0.31- 0.55 nM)

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