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Cayman Chemical GlImepIrIde 500mg
Supplier: Cayman Chemical 12090500 MG
An inhibitor of SUR1/Kir6.2, SUR2A/Kir6.2, and SUR2B/Kir6.2 (IC50s = 3, 5.4, and 7.3 nM, respectively, in Xenopus oocytes expressing the mouse receptor); induces InsR complex dissociation and insulin degradation in HepG2 cells at 20 µM; decreases blood glucose and plasma insulin levels in a KKAy mouse model of insulin-resistant type 2 diabetes at 0.05 mg/kg per day; reduces HbA1c levels in the same model at 0.5 mg/kg per day
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