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Apexbio Technology LLC GLPG0634 1206161-97-8 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B11305.1
GLPG0634 (CAS 1206161-97-8) is a selective small-molecule inhibitor targeting Janus kinase 1 (JAK1) It exhibits potent inhibitory activity against JAK1 and moderate inhibition against JAK2 with reported IC50 values of approximately 10 nM and 28 nM respectively GLPG0634 preferentially interferes with signal transduction pathways mediated by JAK1 affecting cytokine-induced phosphorylation of STAT1 and STAT5 thus attenuating differentiation of Th1 Th2 and to a lesser degree Th17 cells In preclinical rat models of collagen-induced arthritis oral administration reduced inflammatory cell infiltration and bone damage supporting its potential application in inflammatory disease research
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