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Medchemexpress LLC GLPG3970 | 2403733-82-2 | C25H27F3N4O4 | 250 MG
Supplier: Medchemexpress LLC 250MGHY150203
GLPG3970 is a first-in-class SIK2/SIK3 inhibitor intended for research related to inflammation and autoimmune diseases. It has been investigated in clinical trials for conditions such as Systemic Lupus Erythematosus, Ulcerative Colitis, and Rheumatoid Arthritis.
- Acts as a SIK2/SIK3 inhibitor
- Supports research in inflammation and autoimmune diseases
- Induces IL-10 expression in human CD14+ monocytes with an EC50 of 1087 nM
- Reduces LPS-stimulated TNF-alpha production in human CD14+ monocytes with an IC50 of 133 nM
- Decreases ear thickness in murine models of psoriatic-like epidermal hyperplasia
- Improves clinical manifestations in murine collagen-antibody induced arthritis models
- Reduces disease activity index in mice T cell transfer models
- Investigated in clinical trials for various conditions
- High purity: 99.70%
- Solid, white to off-white appearance
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