Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 5000354186

Medchemexpress LLC Glucosylceramide synthase-IN-2 | 2597958-02-4 | 98.62% | C22H20F3N3O4 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY14426710MM/1ML

Encompass_Preferred

Glucosylceramide synthase-IN-2 is a potent, brain-penetrant, and orally active inhibitor of glucosylceramide synthase (GCS). It demonstrates IC50 values of 15 nM for human GCS and 190 nM for mouse GCS, exhibiting noncompetitive inhibition with C8-ceramide and UDP-glucose. This compound is applicable for research related to Gaucher's disease, showing no significant inhibitory activity against SERT or GCase in vitro. In vivo studies confirm good oral and brain exposure in mice, reducing GlcCer concentrations in plasma and cerebral cortex.

  • Potent GCS inhibitor
  • Brain-penetrant
  • Orally active
  • Noncompetitive inhibition type with C8-ceramide and UDP-glucose
  • Useful for Gaucher's disease research
  • Does not significantly inhibit SERT or GCase activity in vitro
  • Shows good oral and brain exposure in vivo

Catalog No. 50-003-54186


May include imposed supplier surcharges.
Add to Cart

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.