Glycine ethyl ester hydrochloride, 99%

Catalog No.	Quantity
AAA1031522	100 g
AAA1031536	500 g
AAA103150E	2500 g

Catalog No. AAA1031522 Supplier Thermo Scientific Chemicals Supplier No. A1031522

Description

CAS: 623-33-6 | C4H10ClNO2 | 139.579 g/mol

Glycine ethyl ester (GEE) is used in conjunction with N-(3-Dimethylaminopropyl)-N?-ethylcarbodiimide (EDC) for carboxyl-foot printing studies of proteins. The GEE/EDC protocol effects specific derivatization of glutamate and aspartate carboxyl side chains on intact proteins. This reaction is readily done under aqueous conditions at physiological pH. It is mainly used as a pharmaceutical raw material. Glycine ethyl ester hydrochloride is an important intermediate for preparing chrysanthemic acid or two chlorine chrysanthemic acid and is mainly used in the synthesis of anti-inflammatory drugs, but also can be used for the synthesis of four imidazole acetic acid.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Glycine ethyl ester (GEE) is used in conjunction with N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide (EDC) for carboxyl-foot printing studies of proteins. The GEE/EDC protocol effects specific derivatization of glutamate and aspartate carboxyl side chains on intact proteins. This reaction is readily done under aqueous conditions at physiological pH. It is mainly used as a pharmaceutical raw material. Glycine ethyl ester hydrochloride is an important intermediate for preparing chrysanthemic acid or two chlorine chrysanthemic acid and is mainly used in the synthesis of anti-inflammatory drugs, but also can be used for the synthesis of four imidazole acetic acid.

Solubility
Soluble in water (>1000 mg/ml at 20°C), ethanol, DMSO, and methanol.

Notes
Hygroscopic. Store away from oxidizing agents and water/moisture. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas. Protect from humidity.

Specifications

Chemical Identifiers

• CAS: 623-33-6
• Molecular Formula: C4H10ClNO2
• Molecular Weight (g/mol): 139.579
• MDL Number: MFCD00012871
• InChI Key: TXTWXQXDMWILOF-UHFFFAOYSA-N
• Synonym: glycine ethyl ester hydrochloride, ethyl glycinate hydrochloride, ethyl 2-aminoacetate hydrochloride, h-gly-oet.hcl, glycine, ethyl ester, hydrochloride, ethyl aminoacetate hydrochloride, glycine hydrochloride ethyl ester, amino-acetic acid ethyl ester hydrochloride, glycine ethyl ester hydrochloric acid, glycineethylesterhydrochlor
• PubChem CID: 2723640
• IUPAC Name: ethyl 2-aminoacetate;hydrochloride
• SMILES: CCOC(=O)CN.Cl

• Melting Point: 144°C to 148°C
• Beilstein: 3594034
• Solubility Information: Soluble in water (>1000mg/ml at 20°C),ethanol,DMSO,and methanol.
• Quantity: 100 g
• Formula Weight: 139.58
• Sensitivity: Hygroscopic
• Percent Purity: 99%
• Chemical Name or Material: Glycine ethyl ester hydrochloride

Safety and Handling

Hazard Category	Danger
Hazard Statement	GHS H Statement H318 Causes serious eye damage.
Precautionary Statement	GHS P Statement P280-P305+P351+P338-P310 Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.
EINECSNumber	210-787-4
RTECSNumber	MC0525000
TSCA	Yes
Recommended Storage	Ambient temperatures; Store under Nitrogen

SDS

RUO – Research Use Only