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Medchemexpress LLC Glycocholic acid | 475-31-0 | 465.62 | 1 G
SDP

Supplier:  Medchemexpress LLC HYN14231G

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Glycocholic acid is an endogenous metabolite and a bile acid that exhibits anticancer activity by targeting both pump resistance-related and non-pump resistance-related pathways. It is suitable for research applications.

  • Bile acid with anticancer activity.
  • Targets pump resistance-related pathways.
  • Targets non-pump resistance-related pathways.
  • Increases cytotoxicity and intracellular accumulation of epirubicin in Caco-2 cells.
  • Increases absorption of epirubicin in rat small intestine.
  • Intensifies epirubicin-induced apoptosis.
  • Downregulates MDR1, MRP1, and MRP2 mRNA expression.
  • Suppresses Bcl-2 mRNA and induces Bax mRNA.
  • Increases Bax-to-Bcl-2 ratio and mRNA levels of p53, caspase-9 and -3.
  • Exhibits agonist activity on TGR5 in CHO cells (EC50 = 13.6 μM).
  • Inhibits E217betaG uptake in MRP4-expressing HEK293 cells (IC50 = 400 μM).

Catalog No. 50-004-14651


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