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Medchemexpress LLC Glycocholic acid | 475-31-0 | 465.62 | 10 G
Supplier: Medchemexpress LLC HYN142310G
Glycocholic acid is a bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways. It works by modulating P-gp and MRPs, and regulating apoptosis-related pathways when combined with anticancer drugs.
- Increases cytotoxicity of epirubicin
- Increases intracellular accumulation and absorption of epirubicin
- Intensifies epirubicin-induced apoptosis
- Reduces mRNA expression levels of human intestinal MDR1, MDR-associated protein (MRP)1, and MRP2
- Downregulates the MDR1 promoter region
- Suppresses mRNA expression of Bcl-2
- Induces mRNA expression of Bax
- Increases Bax-to-Bcl-2 ratio and mRNA levels of p53, caspase-9 and -3
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