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Medchemexpress LLC Glycocholic acid | 475-31-0 | 465.62 | 25 G
Supplier: Medchemexpress LLC 25GHYN1423
Glycocholic acid is a bile acid that exhibits anticancer activity by targeting both pump resistance-related and non-pump resistance-related pathways. It is classified as an endogenous metabolite and a human gut microbiota metabolite.
- Increases cytotoxicity of epirubicin
- Significantly increases intracellular accumulation and absorption of epirubicin
- Intensifies epirubicin-induced apoptosis
- Reduces mRNA expression levels of human intestinal MDR1, MRP1, and MRP2
- Downregulates the MDR1 promoter region
- Suppresses mRNA expression of Bcl-2
- Induces mRNA expression of Bax
- Significantly increases Bax-to-Bcl-2 ratio and mRNA levels of p53, caspase-9 and -3
- Controls multidrug resistance (MDR) by modulating P-gp and MRPs
- Regulates apoptosis-related pathways
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