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Medchemexpress LLC Glycocholic acid | 475-31-0 | 465.62 | 25 G
SDP

Catalog No. 5000389424
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Glycocholic acid is a bile acid that exhibits anticancer activity by targeting both pump resistance-related and non-pump resistance-related pathways. It is classified as an endogenous metabolite and a human gut microbiota metabolite.

  • Increases cytotoxicity of epirubicin
  • Significantly increases intracellular accumulation and absorption of epirubicin
  • Intensifies epirubicin-induced apoptosis
  • Reduces mRNA expression levels of human intestinal MDR1, MRP1, and MRP2
  • Downregulates the MDR1 promoter region
  • Suppresses mRNA expression of Bcl-2
  • Induces mRNA expression of Bax
  • Significantly increases Bax-to-Bcl-2 ratio and mRNA levels of p53, caspase-9 and -3
  • Controls multidrug resistance (MDR) by modulating P-gp and MRPs
  • Regulates apoptosis-related pathways

Catalog No. 50-003-89424 Supplier Medchemexpress LLC Supplier No. 25GHYN1423
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Glycocholic acid is a bile acid that exhibits anticancer activity by targeting both pump resistance-related and non-pump resistance-related pathways. It is classified as an endogenous metabolite and a human gut microbiota metabolite.

  • Increases cytotoxicity of epirubicin
  • Significantly increases intracellular accumulation and absorption of epirubicin
  • Intensifies epirubicin-induced apoptosis
  • Reduces mRNA expression levels of human intestinal MDR1, MRP1, and MRP2
  • Downregulates the MDR1 promoter region
  • Suppresses mRNA expression of Bcl-2
  • Induces mRNA expression of Bax
  • Significantly increases Bax-to-Bcl-2 ratio and mRNA levels of p53, caspase-9 and -3
  • Controls multidrug resistance (MDR) by modulating P-gp and MRPs
  • Regulates apoptosis-related pathways

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