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Medchemexpress LLC Glycocholic acid | 475-31-0 | 465.62 | 500 MG
SDP

Supplier:  Medchemexpress LLC HYN1423500MG

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Glycocholic acid is a bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways. For research use only. Not sold to patients.

  • Increases the cytotoxicity of epirubicin.
  • Significantly increases intracellular accumulation of epirubicin in Caco-2 cells and absorption in rat small intestine.
  • Intensifies epirubicin-induced apoptosis.
  • Reduces mRNA expression of human intestinal MDR1, MRP1, and MRP2.
  • Downregulates the MDR1 promoter region.
  • Suppresses mRNA expression of Bcl-2 and induces mRNA expression of Bax.
  • Significantly increases the Bax-to-Bcl-2 ratio and mRNA levels of p53, caspase-9 and -3.
  • Can control multidrug resistance (MDR) by modulating P-gp and MRPs, and regulating apoptosis-related pathways.

Catalog No. 50-004-16266


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