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Medchemexpress LLC Glycocholic acid sodium | 863-57-0 | 487.60 | 100 MG
SDP

Catalog No. 5000414696
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Glycocholic acid sodium is an orally active bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways. It enhances the cytotoxicity and intracellular accumulation of epirubicin in Caco-2 cells and rat small intestine.

  • Increases the cytotoxicity of epirubicin.
  • Enhances intracellular accumulation of epirubicin.
  • Intensifies epirubicin-induced apoptosis.
  • Reduces mRNA expression levels of human intestinal MDR1, MRP1, and MRP2.
  • Downregulates MDR1 promoter region.
  • Suppresses mRNA expression of Bcl-2.
  • Induces mRNA expression of Bax.
  • Significantly increases the Bax-to-Bcl-2 ratio.
  • Increases mRNA levels of p53, caspase-9 and -3.
  • Can control multidrug resistance via modulating P-gp and MRPs.
  • Regulates apoptosis-related pathways.

Catalog No. 50-004-14696 Supplier Medchemexpress LLC Supplier No. HYN1423A100MG
May include imposed supplier surcharges.
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Glycocholic acid sodium is an orally active bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways. It enhances the cytotoxicity and intracellular accumulation of epirubicin in Caco-2 cells and rat small intestine.

  • Increases the cytotoxicity of epirubicin.
  • Enhances intracellular accumulation of epirubicin.
  • Intensifies epirubicin-induced apoptosis.
  • Reduces mRNA expression levels of human intestinal MDR1, MRP1, and MRP2.
  • Downregulates MDR1 promoter region.
  • Suppresses mRNA expression of Bcl-2.
  • Induces mRNA expression of Bax.
  • Significantly increases the Bax-to-Bcl-2 ratio.
  • Increases mRNA levels of p53, caspase-9 and -3.
  • Can control multidrug resistance via modulating P-gp and MRPs.
  • Regulates apoptosis-related pathways.

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