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Thermo Scientific™ GlycoLink™ Coupling Catalyst

Catalog No. PI88944
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100 mL
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PI88944 100 mL
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Catalog No. PI88944 Supplier Thermo Scientific™ Supplier No. 88944
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Description

Enhance aldehyde-hydrazide crosslinking efficiency for glycoprotein immobilization and conjugation with analine (CAS 62-53-3) and an optimized buffer system.

The Thermo Scientific™ GlycoLink Coupling Catalyst decreases reaction times and increases aldehyde-hydrazide coupling efficiency, resulting in greater than 90% coupling of glycoproteins in 4 hours.

The GlycoLink Coupling Catalyst is a two-component kit composed of aniline and sodium acetate buffer. The catalyst accelerates the coupling rate of hydrazide and alkoxyamine moieties with reactive aldehydes that have been generated by periodate-oxidation of cis-diols in glycoproteins. The GlycoLink Coupling Catalyst increases the coupling efficiency of these reactions, decreasing the molar excess amounts of labeling reagents that are required for conjugation reactions. The catalyst is also useful for increasing the binding efficiency of oxidized glycoproteins or other carbohydrate-containing molecules to hydrazide resins.

Highlights:

  • Optimized – catalyzes aldehyde-hydrazide and aldehyde-alkoxyamine conjugation reaction

  • Efficient – maximizes coupling efficiency and decreases required coupling reaction incubation time

  • Gentle – does not interfere with protein function and is easily removed by desalting or dialysis

Recommended for:

Labeling aldehyde-containing molecules with alkoxyamine-biotins; Labeling aldehyde-containing molecules with hydrazide-biotins; Increase coupling efficiency of aldehyde-containing molecules to hydrazide resin

TRUSTED_SUSTAINABILITY

Specifications

Content And Storage Store at 4°C.
Product Line GlycoLink
Form Liquid
Quantity 100 mL
Product Type Coupling Catalyst

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov

For Research Use Only. Not for use in diagnostic procedures.

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