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Sigma Aldrich Fine Chemicals Biosciences Glyoxalase I Activity Assa
Supplier: Sigma Aldrich Fine Chemicals Biosciences MAK1141KT
Glyoxalase I (GLO-1) a lactoylglutathione lyase also known as methylglyoxalase aldoketomutase ketone-aldehyde mutase and (R)-S-lactoylglutathione methylglyoxal-lyase is an enzyme that catalyzes the isomerization of hemithioacetal adducts which are formed in spontaneous reactions between glutathionyl groups and aldehydes. The primary physiological function of glyoxalase I is the detoxification of methyglyoxal a reactive 2-oxoaldehyde that is cytostatic at low concentrations and cytotoxic at millimolar concentrations. Glyoxalase I is a target for the development of pharmaceuticals against bacteria protozoans and cancer.
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