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Cayman Chemical GlypIcn3 RabbIt MoncLNal 25tSt

Supplier: Cayman Chemical 3700825 TEST

A non-peptidomimetic inhibitor of IAP protein-peptide interactions inhibits the protein-peptide interaction between the IAP1 and XIAP BIR3 domains with a Smac-derived peptide in cell-free assays (IC50s 50 2.8 nM) induces displacement of Smac from XIAP in A375 melanoma cells induces apoptosis in MDA-MB-231 A375 and SK-MEL-28 cells in a TNF-a-dependent manner reduces tumor growth in MDA-MB-231 and A375 mouse xenograft models at 20 mg/kg
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