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Enzo Life Sciences GM-6001 (5mg). CAS: 142880-36-2
Supplier: Enzo Life Sciences BMLEI3000005
Potent broad-spectrum hydroxamate inhibitor of matrix metalloproteinases (MMPs). Ki values have been reported for the following human MMPs: MMP-1 (fibroblast collagenase): 0.4nM; MMP-2 (gelatinase A): 0.5nM; MMP-3 (stromelysin-1): 27nM; MMP-7 (matrilysin): 3.7nM; MMP-8 (neutrophil collagenase): 0.1nM; MMP-9 (gelatinase B): 0.2nM; MMP-12 (metalloelastase): 3.6nM; MMP-14 (MT1-MMP): 13.4nM; MMP-26 (endometase): 0.36nM. Also inhibits MMP-10, MMP-13, MMP-15, MMP-17, MMP-20, MMP-21, TACE, ADAM19, other ADAMs, anthrax lethal factor, neprilysin, leucine aminopeptidase, and DPPIII. Typical concentration range for use in tissue culture is 10-25µM. This inhibitor has also been used in vivo. Alternative name: Galardin, Ilomastat, N-[(2R)-2-(Hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan methylamide. Formulation: Lyophilized solid. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO (at least 25mM) or 100% ethanol (10mg/ml). Long Term Storage: -20°C.
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