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Medchemexpress LLC GM-60186 | 99.3% | 504.59 | 1 ML
Supplier: Medchemexpress LLC HY16922910MM/1ML
GM-60186 is a 5-HT receptor 2B (HTR2B) inhibitor with an IC50 of 257 nM. It significantly inhibits colorectal cancer proliferation and migration.
- Inhibits HTR2B with an IC50 of 257 nM.
- Demonstrates anti-colorectal cancer activity.
- In vitro, it effectively inhibits proliferation in colorectal cancer (CRC) cells (COLO-205, MC38, CT26, and Caco2 cells) at concentrations of 50-500 nM over 72 hours.
- Effectively inhibits colorectal cancer migration at 500 nM over 24-48 hours.
- In vivo, it significantly reduces tumor size and weight in xenograft mouse models at doses of 10-20 mg/kg, administered daily for 20 days.
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