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Apexbio Technology LLC GMX1778 (CHS828) 200484-11-3 10mM (in 1mL DMSO)
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Supplier:  Apexbio Technology LLC B60315.1

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GMX1778 (CHS828 CAS 200484-11-3) is a small-molecule inhibitor targeting nicotinamide phosphoribosyltransferase (NAMPT) an enzyme crucial for NAD biosynthesis with a reported Kd value of 120 nM NAD functions as a cofactor essential for enzymatic oxidation-reduction processes and diverse cellular events including metabolism genomic integrity calcium signaling aging and apoptosis In cultured IM-9 cells exposure to GMX1778 substantially decreases NAD and NM levels in a time-dependent manner GMX1778 displays anti-tumor activity preferentially in NAPRT1-deficient cancer models highlighting its potential utility for investigating metabolic vulnerabilities and targeted cancer therapies

Catalog No. 50-000-62867


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