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Medchemexpress LLC GNE-317 | 1394076-92-6 | 98.8% | 100 MG
SDP

Catalog No. 5000339980
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GNE-317 is a PI3K/mTOR inhibitor that can cross the blood-brain barrier (BBB). It is an oxetane derivative of GDC-0980, synthesized to reduce substrate affinity for efflux transporters. While GNE-317 shows greater delivery and enhanced therapeutic targeting efficacy compared to GDC-0980, it showed limited efficacy in inducing cell death in GL261 cell lines in vitro and was not found effective in vivo in GL261 tumor models.

  • PI3K/mTOR inhibitor
  • Can cross the blood-brain barrier (BBB)
  • Oxetane derivative
  • Greater delivery and enhanced therapeutic targeting efficacy

Catalog No. 50-003-39980 Supplier Medchemexpress LLC Supplier No. HY12763100MG
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GNE-317 is a PI3K/mTOR inhibitor that can cross the blood-brain barrier (BBB). It is an oxetane derivative of GDC-0980, synthesized to reduce substrate affinity for efflux transporters. While GNE-317 shows greater delivery and enhanced therapeutic targeting efficacy compared to GDC-0980, it showed limited efficacy in inducing cell death in GL261 cell lines in vitro and was not found effective in vivo in GL261 tumor models.

  • PI3K/mTOR inhibitor
  • Can cross the blood-brain barrier (BBB)
  • Oxetane derivative
  • Greater delivery and enhanced therapeutic targeting efficacy

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