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Medchemexpress LLC GNE-371 | 1926986-36-8 | 98.1% | 431.49 | 10 MG
SDP

Supplier:  Medchemexpress LLC HY11280310MG

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GNE-371 is a potent and selective chemical probe for the second bromodomains of human transcription-initiation-factor TFIID subunit 1 and transcription-initiation-factor TFIID subunit 1-like. It binds TAF1(2) with an IC50 of 10 nM, showing excellent selectivity over other bromodomain-family members. It is also active in a cellular TAF1(2) target-engagement assay (IC50=38 nM) and demonstrates anti-proliferative synergy with the BET inhibitor JQ1, supporting its use in mechanistic and target-validation studies.

  • Potent and selective chemical probe for the second bromodomains of human transcription-initiation-factor TFIID subunit 1 and transcription-initiation-factor TFIID subunit 1-like.
  • IC50 of 10 nM for TAF1(2).
  • Active in a cellular TAF1(2) target-engagement assay (IC50=38 nM).
  • Exhibits anti-proliferative synergy with the BET inhibitor JQ1.
  • Appearance: Solid, white to off-white.

Catalog No. 50-004-37687


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