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Medchemexpress LLC GNE-371 | 1926986-36-8 | 98.1% | 431.49 | 50 MG
Supplier: Medchemexpress LLC HY11280350MG
GNE-371 is a potent and selective chemical probe designed for the second bromodomains of human transcription-initiation-factor TFIID subunit 1 and transcription-initiation-factor TFIID subunit 1-like. It demonstrates an IC50 of 10 nM for TAF1(2).
- Potent and selective chemical probe for TAF1(2).
- Binds TAF1(2) with an IC50 of 10 nM.
- Maintains excellent selectivity over other bromodomain-family members.
- Active in a cellular-TAF1(2) target-engagement assay (IC50=38 nM).
- Exhibits anti-proliferative synergy with the BET inhibitor JQ1.
- Useful for mechanistic and target-validation studies.
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