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Medchemexpress LLC Gne-493 | 1033735-94-2 | MFCD18251526 | 99.8% | 372.44 g/mol | C17H20N6O2S | 1 ML
SDP

Catalog No. 5000242461
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GNE-493 is a potent, selective, orally available small-molecule inhibitor of class I PI3K isoforms and mTOR, with demonstrated biochemical potency and cellular antiproliferative activity. It is supplied as a solid or as ready-to-use DMSO solutions (for example, 10 mM, 1 mL).

  • Dual pan-PI3K and mTOR inhibition with low-nanomolar IC50s.
  • Biochemical IC50s: PI3Kα 3.4 nM; PI3Kβ 12 nM; PI3Kδ 16 nM; PI3Kγ 16 nM; mTOR 30 nM.
  • Cellular antiproliferative activity (PC-3 IC50 0.33 μM).
  • High purity and defined physicochemical profile (MW 372.44; formula C17H20N6O2S).
  • Available as solution in DMSO or as a solid for custom formulation.

Catalog No. 50-002-42461 Supplier Medchemexpress LLC Supplier No. HY1081110MM 1ML
May include imposed supplier surcharges.
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GNE-493 is a potent, selective, orally available small-molecule inhibitor of class I PI3K isoforms and mTOR, with demonstrated biochemical potency and cellular antiproliferative activity. It is supplied as a solid or as ready-to-use DMSO solutions (for example, 10 mM, 1 mL).

  • Dual pan-PI3K and mTOR inhibition with low-nanomolar IC50s.
  • Biochemical IC50s: PI3Kα 3.4 nM; PI3Kβ 12 nM; PI3Kδ 16 nM; PI3Kγ 16 nM; mTOR 30 nM.
  • Cellular antiproliferative activity (PC-3 IC50 0.33 μM).
  • High purity and defined physicochemical profile (MW 372.44; formula C17H20N6O2S).
  • Available as solution in DMSO or as a solid for custom formulation.

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