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Medchemexpress LLC GNE-7883 | 2648450-42-2 | 99.5% | 500.57 | 100 MG
SDP

Catalog No. 5000362859
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GNE-7883 is a pan-TEAD inhibitor that blocks the association of YAP/TAZ with TEAD. It effectively reduces chromatin accessibility at TEAD motifs, inhibits cell proliferation in multiple cell line models, and shows strong anti-tumor efficacy in vivo. Additionally, GNE-7883 overcomes intrinsic and acquired resistance to KRAS G12C inhibitors.

  • Pan-TEAD inhibitor
  • Blocks YAP/TAZ association with TEAD
  • Reduces chromatin accessibility at TEAD motifs
  • Inhibits cell proliferation
  • Shows anti-tumor efficacy in vivo
  • Overcomes KRAS G12C inhibitor resistance
  • Targets YAP/TAZ-TEAD
  • Soluble in DMSO (50 mg/mL)

Catalog No. 50-003-62859 Supplier Medchemexpress LLC Supplier No. HY147214100MG
May include imposed supplier surcharges.
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GNE-7883 is a pan-TEAD inhibitor that blocks the association of YAP/TAZ with TEAD. It effectively reduces chromatin accessibility at TEAD motifs, inhibits cell proliferation in multiple cell line models, and shows strong anti-tumor efficacy in vivo. Additionally, GNE-7883 overcomes intrinsic and acquired resistance to KRAS G12C inhibitors.

  • Pan-TEAD inhibitor
  • Blocks YAP/TAZ association with TEAD
  • Reduces chromatin accessibility at TEAD motifs
  • Inhibits cell proliferation
  • Shows anti-tumor efficacy in vivo
  • Overcomes KRAS G12C inhibitor resistance
  • Targets YAP/TAZ-TEAD
  • Soluble in DMSO (50 mg/mL)

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