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Apexbio Technology LLC GNE-7915 1351761-44-8 10mM (in 1mL DMSO)
SDP

Catalog No. 5000062711
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GNE-7915 (CAS 1351761-44-8) is a potent selective and brain-penetrant inhibitor of leucine-rich repeat kinase 2 (LRRK2) exhibiting Ki and IC50 values of approximately 1 nM and 9 nM respectively Despite broad kinase screening GNE-7915 demonstrates high selectivity substantially interacting with only a limited set of kinases at 100 nM It notably induces LRRK2 dephosphorylation in brain tissue of transgenic mice and reduces TNF and CXCL10 expression at elevated concentrations ( 3 M) This compound serves as a valuable molecular tool for neurodegenerative disease research involving LRRK2 signaling

Catalog No. 50-000-62711 Supplier Apexbio Technology LLC Supplier No. B36055.1
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GNE-7915 (CAS 1351761-44-8) is a potent selective and brain-penetrant inhibitor of leucine-rich repeat kinase 2 (LRRK2) exhibiting Ki and IC50 values of approximately 1 nM and 9 nM respectively Despite broad kinase screening GNE-7915 demonstrates high selectivity substantially interacting with only a limited set of kinases at 100 nM It notably induces LRRK2 dephosphorylation in brain tissue of transgenic mice and reduces TNF and CXCL10 expression at elevated concentrations ( 3 M) This compound serves as a valuable molecular tool for neurodegenerative disease research involving LRRK2 signaling

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