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Selleck Chemical LLC GNE-987-E1664-1MG
SDP

Catalog No. 503137173
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GNE-987 is a BRD4-degradating PROTAC consisting of BRD4B1 and BRD4B2 (BRD4 bromodomains 1 and 2) and the VHL E3-ubiquitin ligase It exhibits BRD4 degradation activity with DC50 of 0 03 nM for the EOL-1 AML cell line GNE-987 inhibits cell proliferation and induces apoptosis by promoting the rapid and sustained degradation of BRD4 and inhibiting its downstream targets It also demonstrates potent antitumor activity in AML cell lines

Catalog No. 50-313-7173 Supplier Selleck Chemical LLC Supplier No. E16641MG
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GNE-987 is a BRD4-degradating PROTAC consisting of BRD4B1 and BRD4B2 (BRD4 bromodomains 1 and 2) and the VHL E3-ubiquitin ligase It exhibits BRD4 degradation activity with DC50 of 0 03 nM for the EOL-1 AML cell line GNE-987 inhibits cell proliferation and induces apoptosis by promoting the rapid and sustained degradation of BRD4 and inhibiting its downstream targets It also demonstrates potent antitumor activity in AML cell lines

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