Apexbio Technology LLC GNF-5837 1033769-28-6 200mg

Supplier:  Apexbio Technology LLC A8303200

GNF-5837 (CAS 1033769-28-6) is a potent and selective pan-Trk inhibitor exhibiting inhibitory activity against TrkA and TrkB with IC50 values of 8 nM and 12 nM respectively In cellular assays GNF-5837 suppresses proliferation in TRKA/NGF-expressing Ba/F3 and RIE cells with IC50 values of 0 042 M and 0 017 M respectively The compound has also been shown to inhibit c-Kit and PDGFR in select cell models In vivo GNF-5837 demonstrated dose-dependent tumor inhibition in xenograft mouse models derived from TRKA/NGF-expressing RIE cells Its oral bioavailability and specificity make it a valuable tool for investigating TRK signaling in oncogenic processes and other disease models No clinical evaluation has been reported to date

Catalog No. 50-000-92149