Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 5000422897

Medchemexpress LLC GO-203 TFA | 1222186-26-6 | 98.39% | 2426.77 | 10 MG
SDP

Catalog No. 5000422897
Encompass_Preferred

GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. It is an all D-amino acid peptide that consists of a poly-R transduction domain linked to a CQCRRKN motif, which binds to the MUC1-C cytoplasmic tail and blocks MUC1-C homodimerization. This compound downregulates TIGAR protein synthesis by inhibiting the PI3K-AKT-S6K1 pathway. GO-203 TFA also induces the production of reactive oxygen species (ROS) and loss of mitochondrial transmembrane potential, and inhibits the growth of colon cancer cells both in vitro and as xenografts in nude mice.

  • Potent MUC1-C oncoprotein inhibitor
  • Blocks MUC1-C homodimerization
  • Downregulates TIGAR protein synthesis
  • Induces production of reactive oxygen species (ROS)
  • Inhibits growth of colon cancer cells in vitro and as xenografts in nude mice

Catalog No. 50-004-22897 Supplier Medchemexpress LLC Supplier No. HYP1925A10MG
May include imposed supplier surcharges.
Add to Cart
Add to Cart

missing translation for 'validMainframeMsg'

GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. It is an all D-amino acid peptide that consists of a poly-R transduction domain linked to a CQCRRKN motif, which binds to the MUC1-C cytoplasmic tail and blocks MUC1-C homodimerization. This compound downregulates TIGAR protein synthesis by inhibiting the PI3K-AKT-S6K1 pathway. GO-203 TFA also induces the production of reactive oxygen species (ROS) and loss of mitochondrial transmembrane potential, and inhibits the growth of colon cancer cells both in vitro and as xenografts in nude mice.

  • Potent MUC1-C oncoprotein inhibitor
  • Blocks MUC1-C homodimerization
  • Downregulates TIGAR protein synthesis
  • Induces production of reactive oxygen species (ROS)
  • Inhibits growth of colon cancer cells in vitro and as xenografts in nude mice

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.