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Medchemexpress LLC GO-203 TFA | 1222186-26-6 | 98.39% | 2426.77 | 10 MG
Supplier: Medchemexpress LLC HYP1925A10MG
GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. It is an all D-amino acid peptide that consists of a poly-R transduction domain linked to a CQCRRKN motif, which binds to the MUC1-C cytoplasmic tail and blocks MUC1-C homodimerization. This compound downregulates TIGAR protein synthesis by inhibiting the PI3K-AKT-S6K1 pathway. GO-203 TFA also induces the production of reactive oxygen species (ROS) and loss of mitochondrial transmembrane potential, and inhibits the growth of colon cancer cells both in vitro and as xenografts in nude mice.
- Potent MUC1-C oncoprotein inhibitor
- Blocks MUC1-C homodimerization
- Downregulates TIGAR protein synthesis
- Induces production of reactive oxygen species (ROS)
- Inhibits growth of colon cancer cells in vitro and as xenografts in nude mice
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