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Apexbio Technology LLC Golgicide A 1139889-93-2 10mM (in 1mL DMSO)
SDP

Catalog No. 5000062625
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Golgicide A is a reversible small-molecule inhibitor targeting the guanine nucleotide exchange factor GBF1 GBF1 functions as an ArfGEF facilitating Arf1 activation and COPI recruitment at the cis-Golgi membranes essential for Golgi structure maintenance and protein transport regulation Golgicide A disrupts Golgi morphology leading to dispersion of Golgi markers and altered COPI localization In cellular assays Golgicide A inhibits shiga toxin-mediated protein synthesis with an IC50 of approximately 3 3 M in Vero cells and impairs retrograde toxin trafficking and secretory protein transport Additionally Golgicide A is applied in HCV research to reduce viral RNA replication and alter NS5A localization causing accumulation of viral particles in infected cells

Catalog No. 50-000-62625 Supplier Apexbio Technology LLC Supplier No. B13855.1
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Golgicide A is a reversible small-molecule inhibitor targeting the guanine nucleotide exchange factor GBF1 GBF1 functions as an ArfGEF facilitating Arf1 activation and COPI recruitment at the cis-Golgi membranes essential for Golgi structure maintenance and protein transport regulation Golgicide A disrupts Golgi morphology leading to dispersion of Golgi markers and altered COPI localization In cellular assays Golgicide A inhibits shiga toxin-mediated protein synthesis with an IC50 of approximately 3 3 M in Vero cells and impairs retrograde toxin trafficking and secretory protein transport Additionally Golgicide A is applied in HCV research to reduce viral RNA replication and alter NS5A localization causing accumulation of viral particles in infected cells

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