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Enzo Life Sciences Gossypol (100mg). CAS: 303-45-7
Supplier: Enzo Life Sciences BMLEI1300100
Mixture of ~65% (+)- and ~35% (-)-enantiomers. Male antifertility agent with antispermatogenic activity. Shows antitumor, antiviral and antioxidant actions. Small molecule inhibitor of Bcl-2/Bcl-XL. Induces apoptosis. Synergizes with radiation and chemotherapy in vitro. Reversible inhibitor of protein phosphatase 2B (PP2B; calcineurin). Protein kinase C (PKC) inhibitor. Inhibits activities of the mitotic kinesin Eg5 (IC50=10.8µM/L). Inhibits RBL-1, 5-lipoxygenase (IC50=0.3µM) and 12-lipoxygenase (IC50=0.7µM). Inhibits PAF and leukotriene-induced guinea pig parenchyma contractions. Novel direct-acting inhibitor of calcineurin. Alternative name: 2,2'-bis[8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene]. Purity: ≥90% (HPLC). Solubility: Soluble in 100% ethanol (25mg/ml), dimethylformamide (25mg/ml), acetone or DMSO; sparingly soluble in methanol (2mg/ml); insoluble in water. Long Term Storage: -20°C.
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